Immunity & Inflammation

Researchers at VIB focus on the molecular and cellular mechanisms behind inflammation in pathologies. Through a multidisciplinary approach, molecular biologists, bioinformaticians, and clinicians aim to translate basic research into novel diagnostics and more effective therapies for patients.

To unravel the molecular mechanisms driving inflammation, and transform them into innovative applications, researchers are supported by cutting-edge technologies and contribute to the development of tools for practical use in the clinic.

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Impact on society

Understanding primary immune deficiencies

PID

Improving our understanding and diagnosis of life-threatening genetic disorders of the innate and adaptive immune system in the primary immune deficiency (PID) project.
Preventing arthritis relapse

Spartacus (Ongoing)

Inducing drug-free remission in spondyloarthritis patients by early treatment with biologicals under guidance of single-cell and epigenetic profiling in the Spartacus project.
Targeting drugs to the brain

Blood Brain Barrier Project

Developing a platform to find nanobody constructs that can cross the blood-brain barrier, as a way of treating brain diseases in the blood-brain-barrier (BBB) project.
Contagious

Contagious

An in-dept characterization of the dynamic immune response to coronavirus SARS-CoV-2 in the Contagious project.
SARPAC

SARPAC

Investigating immune stimulators as a treatment option for patients with acute hypoxic respiratory failure due to COVID-19 in the Sarpac project.
COV-AID

COV-AID

Investigating anti-rheumatic drugs as a treatment option for patients with a cytokine storm due to COVID-19 in the Covaid project.

Center for Inflammation Research

The scientific investigation of the various research groups in the VIB-UGent Center for Inflammation research (IRC) is focused on molecular mechanisms of inflammation in pathologies such as allergy, autoimmune diseases, cancer, infectious diseases and senescence. At the heart of this research is the investigation of inter- and intracellular signaling pathways in innate and adaptive immune cells and barrier cells of the skin, lung and gut.

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