Nanobodies® are an extremely useful class of molecules for research, diagnostics and therapeutics in human and animal health. You can use them in a wide variety of fields, such as immunohistochemistry, immunomodulation, intracellular expression (intrabodies) and biosensor-applications. As proteomics tools, you can deploy them for expression profiling, physical mapping of proteins, protein-protein interaction studies, functional analysis and (in)activation of genens. Developed at the Vrije Universiteit Brussel, Belgium, the powerful Nanobody® technology is now available to all academic researchers through the VIB Nanobody Service Facility (NSF).
Nanobodies® combine the advantages of conventional antibodies with important features of small molecules. Like conventional antibodies, Nanobodies® show:
- high-target specificity and affinity
- low inherent toxicity
And, like small molecules, they can be tweaked to inhibit enzymes and readily access clefts and cavities. Furthermore, Nanobodies®:
- are extremely stable
- have an almost limitless repertoire diversity
- are easy to manufacture
The affinity of the Nanobody® is usually in the range of 0.1 to 100 nM for protein antigens, and 0.1 to 10 µM for peptides/haptens.
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