VIB scientists overview

Inflammation and immunity

  • Patrizia Agostinis Lab

    ​“We are studying cell death and resistance pathways in tumors, how they impact the interface between cancer cells and stromal cells, modify the tumor microenvironment and anticancer therapy responses. Our ultimate goal is to contribute to combating cancer by translating molecular/cellular knowledge into therapeutic possibilities”​
  • Gabriele Bergers Lab

    • Functional irregulation of the tumor microenvironment and tumor cell compartment
    • Tumor niches and therapeutic resistance
    • Resistance to antiangiogenic therapy
    • Vascular and immunomodulation in cancer
  • Rudi Beyaert Lab

    • Protein-protein interactions, phosphorylation and ubiquitination
    • Cytokine, Toll-like receptor and T cell receptor signal transduction
    • NF-kappaB signaling in inflammation and cancer
    • Novel therapeutic targets and tools
  • Karolien De Bosscher Lab

    • Nuclear Receptors - Understand how these transcription factors interact and crosstalk at the genome-wide level
    • ​Glucocorticoid Receptor – Develop drug discovery platforms
     
  • Dirk Elewaut Lab

    • ​Mucosal inflammation and its link to joint disease
    • Immune regulation in health and arthritic disease with focus on iNKT cells and Tregs
    • Cellular stress and lipid homeostasis during autoimmune disease
    • Biomechanical stress in arthritis
    • Cartilage and bone homeostasis in steady state and in arthritic disease
  • Martin Guilliams Lab

    • ​​ERC group
    • Ontogeny of dendritic cells and macrophages
    • Functional characterization of dendritic cell and macrophage subsets across species and tissues in steady state and inflammation

  • Bart Lambrecht and Hamida Hammad Lab

    • ​Study of the molecular mechanism of DC-epithelial interaction in asthma and how this is influenced by infection and environment.
    • Study how the unfolded protein response interferes with the functioning of cells in the immune system and how this might lead to lung disease.
  • Sophie Janssens Lab

    • ​ ​the IRE1 signaling branch in dendritic cells
    • the role of IRE1b in lung and colon epithelial  cells
    • TAOK3 as a regulator of metabolic responses
    • Ormdl3 and house-dust mite driven asthma​​
  • Markus Kleinewietfeld Lab

    • ERC group
    • the immune cell balance as key regulator of human (auto)immune diseases
    • environmental factors in autoimmunity
    • plasticity of CD4+ T cells in health and disease
  • Bart Lambrecht and Hamida Hammad Lab

    • ​Study of the molecular mechanism of DC-epithelial interaction in asthma and how this is influenced by infection and environment.
    • Study how the unfolded protein response interferes with the functioning of cells in the immune system and how this might lead to lung disease.
  • Claude Libert Lab

    • ​therapeutic potential of cytokines and their control mechanisms
    • matrix metalloproteinases (MMPs) and inflammation
    • determination of health status during aging
  • Adrian Liston Lab

    • ERC group
    • understanding the human immune system in health and during disease
    • biology of regulatory T cells
    • mechanisms of diabetes and development of new models for screening anti-diabetic drugs
  • Kodi Ravichandran Lab

    • ​Mechanisms of apoptotic cell clearance - genes, molecules, and pathways
    • Mouse models of human diseases influenced by impaired cell clearance
    • Drug discovery and targeting of specific engulfment pathways
  • Xavier Saelens Lab

    • ​development of broad (universal) human influenza vaccines for both influenza A en B virus strains
  • Yvan Saeys Lab

    • ​data mining and modeling for systems immunology
    • automation and design of novel computational tools to analyze data from high-throughput technologies
    • machine learning and automated reasoning for biomedical applications
  • Savvas Savvides Lab

    • ​Pro-inflammatory signaling complexes 
    • Extracellular assembly and activation principles of oncogenic receptor tyrosine kinases
    • in vivo protein crystals in immunity, inflammation and cancer
    • structure-guided protein engineering and drug/antagonist design
  • Jan Tavernier Lab

    • ERC group
    • leptin receptors: molecular mechanisms underlying receptor activation upon ligand binding
    • MAPPIT two-hybrid toolbox based on JAK/STAT pathway
    • protein interactions important in the innate immune response
  • Jo Van Ginderachter Lab

    • ​myeloid cell heterogeneity and functions - functional genomics
    • Nanobodies against myeloid cell/inflammation markers
    • Tumor-host interactions
    • Trypanosome-host interactions
  • Geert van Loo Lab

    • NF-kB in inflammatory disease pathology
    • ER stress in inflammatory disease pathology
    • A20 in inflammation and autoimmune pathology
    • Development of new transgenic mouse models
  • Peter Vandenabeele Lab

    • cell death modalities in vivo
    • in vivo focus on epithelial biology: skin and intestine
    • transgenic mouse models for caspases and RIP kinases
  • Roos Vandenbroucke Lab

    • ​​Blood-brain (BBB) and blood-cerebrospinal fluid (BCSFB) barrier
    • Novel delivery strategies to target the brain
  • Thomas Voets Lab

    • ​​TRP Ion Channels - Biophysics, function, (patho)physiology
    • Molecular and cellular basis of somatosensation
    • Pain - from molecular mechanisms to analgesic drug development