VIB scientists overview

Cancer

  • Stein Aerts Lab

    • ERC group​
    • cellular decision making and genome regulation
    • single-cell transcriptomics and epigenomics
    • systems biology of gene regulation
    • gene regulatory networks in the Drosophila brain and retina
    • high-throughput enhancer assays and computational enhancer models
  • Patrizia Agostinis Lab

    ​“We are studying cell death and resistance pathways in tumors, how they impact the interface between cancer cells and stromal cells, modify the tumor microenvironment and anticancer therapy responses. Our ultimate goal is to contribute to combating cancer by translating molecular/cellular knowledge into therapeutic possibilities”​
  • Gabriele Bergers Lab

    • Functional irregulation of the tumor microenvironment and tumor cell compartment
    • Tumor niches and therapeutic resistance
    • Resistance to antiangiogenic therapy
    • Vascular and immunomodulation in cancer
  • Cédric Blanpain Lab*

    • ​ERC group
    • embryonic development
    • stem cells and adult homeostasis
    • stem cells and tumor initiation
    • cancer stem cells
  • Peter Carmeliet Lab

    • ERC group​
    • Vascular metabolism & (lymph)angiogenesis
    • Omics analysis of healthy and diseased human and mouse endothelial/vascular cells to understand and target metabolic pathways
    • Therapeutic anti-angiogenesis: tumor vessel normalization (TVN)
    • Endothelial cell metabolic target discovery and drug development
  • Jan Cools Lab

    • ERC group
    • ​novel oncogenic mutations in leukemia
    • targeting deregulated pathways for leukemia therapy
    • cooperation of oncogenes during leukemogenesis
  • Karolien De Bosscher Lab

    • Nuclear Receptors - Understand how these transcription factors interact and crosstalk at the genome-wide level
    • ​Glucocorticoid Receptor – Develop drug discovery platforms
     
  • Sarah-Maria Fendt Lab

    • ERC group
    • Cancer cells have a distinct metabolism adapted to their proliferative needs
    • Our focus is centered on understanding and targeting the differential metabolism of cancer cells
  • Metabolomics Expertise Center

    • ​metabolism: (un)targeted profiling of diverse classes of metabolites
    • mass spectrometry: gas and liquid chromatography set-ups
    • metabolic crosstalk: epigenetics, protein modifications, ....
    • 13C metabolic tracer studies
  • Georg Halder Lab

    • ​Mechanisms that control organ growth, cancer and regeneration
    • Liver cancer and liver regeneration
    • The Hippo signaling pathway
    • Regenerative biology
    • Mouse and Drosophila genetics
  • Diether Lambrechts Lab

    • ERC group
    • Leverage the genetic and epigenetic annotation of tumors to improve cancer prevention, diagnosis, prognosis and therapy
    • Apply cutting-edge genetic technologies and bioinformatics and integrate genomic data sets with clinical and fundamental biological information
    • To characterize how the tumor microenvironment influences tumor cells and determines response to cancer therapies
  • Claude Libert Lab

    • ​therapeutic potential of cytokines and their control mechanisms
    • matrix metalloproteinases (MMPs) and inflammation
    • determination of health status during aging
  • Jean-Christophe Marine Lab

    • Melanoma biology and therapy resistance
    • Role of lncRNA in cancer
    • Disease modelling through mouse models (GEMM & PDX)
  • Massimiliano Mazzone Lab

    • ERC group
    • Genetic and molecular mechanisms regulating blood vessel formation
    • Influence of the microenvironment on macrophage phenotypes and positioning in the context of cancer and ischemia
    • Metabolic control of tumor immunity and resistance to immunotherapy
  • Joris Messens Lab

    • Study of the proteins and mechanisms that control redox homeostasis
    • Biochemical, structural and quantum chemical expertise in thiol/redox-chemistry
  • Anna Sablina Lab

    • ERC group
    • ​protein phosphatase complexes involved in control of cell transformation
    • models of cell transformation derived from manipulation of oncogenes and tumor suppressor genes
  • Jo Van Ginderachter Lab

    • ​myeloid cell heterogeneity and functions - functional genomics
    • Nanobodies against myeloid cell/inflammation markers
    • Tumor-host interactions
    • Trypanosome-host interactions
  • Peter Vandenabeele Lab

    • cell death modalities in vivo
    • in vivo focus on epithelial biology: skin and intestine
    • transgenic mouse models for caspases and RIP kinases