VIB scientists overview

Mouse

  • Stein Aerts Lab

    • ERC group​
    • cellular decision making and genome regulation
    • single-cell transcriptomics and epigenomics
    • systems biology of gene regulation
    • gene regulatory networks in the Drosophila brain and retina
    • high-throughput enhancer assays and computational enhancer models
  • Patrizia Agostinis Lab

    ​“We are studying cell death and resistance pathways in tumors, how they impact the interface between cancer cells and stromal cells, modify the tumor microenvironment and anticancer therapy responses. Our ultimate goal is to contribute to combating cancer by translating molecular/cellular knowledge into therapeutic possibilities”​
  • Gabriele Bergers Lab

    • Functional irregulation of the tumor microenvironment and tumor cell compartment
    • Tumor niches and therapeutic resistance
    • Resistance to antiangiogenic therapy
    • Vascular and immunomodulation in cancer
  • Rudi Beyaert Lab

    • Protein-protein interactions, phosphorylation and ubiquitination
    • Cytokine, Toll-like receptor and T cell receptor signal transduction
    • NF-kappaB signaling in inflammation and cancer
    • Novel therapeutic targets and tools
  • Cédric Blanpain Lab*

    • ​ERC group
    • embryonic development
    • stem cells and adult homeostasis
    • stem cells and tumor initiation
    • cancer stem cells
  • Vincent Bonin Lab

    • visual processing in the mammalian brain
    • ​network dynamics and computations
    • neural circuits and behavior
  • Peter Carmeliet Lab

    • ERC group​
    • Vascular metabolism & (lymph)angiogenesis
    • Omics analysis of healthy and diseased human and mouse endothelial/vascular cells to understand and target metabolic pathways
    • Therapeutic anti-angiogenesis: tumor vessel normalization (TVN)
    • Endothelial cell metabolic target discovery and drug development
  • Lucía Chávez-Gutiérrez Lab

    • ​​Intramembrane proteolytic mechanism
    • Quantitative enzymology
    • Structure and function of proteases in neurodegeneration
  • Karolien De Bosscher Lab

    • Nuclear Receptors - Understand how these transcription factors interact and crosstalk at the genome-wide level
    • ​Glucocorticoid Receptor – Develop drug discovery platforms
     
  • Bart De Strooper Lab

    • Basic mechanisms of Alzheimer’s and Parkinson’s disease
    • Secretases of the amyloid peptide
    • Intramembrane proteolysis as a signaling mechanism
  • Joris de Wit Lab

    • ERC group
    • ​molecular mechanisms of neuronal connectivity
    • role of cell adhesion molecules in synapse development and function
  • Dirk Elewaut Lab

    • ​Mucosal inflammation and its link to joint disease
    • Immune regulation in health and arthritic disease with focus on iNKT cells and Tregs
    • Cellular stress and lipid homeostasis during autoimmune disease
    • Biomechanical stress in arthritis
    • Cartilage and bone homeostasis in steady state and in arthritic disease
  • Sarah-Maria Fendt Lab

    • ERC group
    • Cancer cells have a distinct metabolism adapted to their proliferative needs
    • Our focus is centered on understanding and targeting the differential metabolism of cancer cells
  • Holger Gerhardt Lab

    • ERC group
    • Importance of tip cell biology in vascular patterning, tumour angiogenesis and ischemic disease

     

  • Rose Goodchild Lab

    • ​Molecular and cellular pathology of hereditary dystonias
    • Dystonia proteins in neurodevelopment
  • Martin Guilliams Lab

    • ​​ERC group
    • Ontogeny of dendritic cells and macrophages
    • Functional characterization of dendritic cell and macrophage subsets across species and tissues in steady state and inflammation

  • Sebastian Haesler Lab

    • ​Reinforcement learning
    • Novelty response
    • Mesoscopic connectivity of neuromodulatory brain circuits
  • Bart Lambrecht and Hamida Hammad Lab

    • ​Study of the molecular mechanism of DC-epithelial interaction in asthma and how this is influenced by infection and environment.
    • Study how the unfolded protein response interferes with the functioning of cells in the immune system and how this might lead to lung disease.
  • Matthew Holt Lab

    • ERC group
    • Basic mechanisms of signal transduction in astrocytes
    • Mechanisms of neuron-astrocyte interaction
    • Role of astrocytes in neuropathology
  • Sophie Janssens Lab

    • ​ ​the IRE1 signaling branch in dendritic cells
    • the role of IRE1b in lung and colon epithelial  cells
    • TAOK3 as a regulator of metabolic responses
    • Ormdl3 and house-dust mite driven asthma​​
  • Markus Kleinewietfeld Lab

    • ERC group
    • the immune cell balance as key regulator of human (auto)immune diseases
    • environmental factors in autoimmunity
    • plasticity of CD4+ T cells in health and disease
  • Fabian Kloosterman Lab

    • Functional and structural organization of memory circuits in the brain
    • Identification of the role of specific brain areas and cell types in memory processing
    • Use of high density electrode arrays to observe neuron-neuron communication in vivo
  • Bart Lambrecht and Hamida Hammad Lab

    • ​Study of the molecular mechanism of DC-epithelial interaction in asthma and how this is influenced by infection and environment.
    • Study how the unfolded protein response interferes with the functioning of cells in the immune system and how this might lead to lung disease.
  • Diether Lambrechts Lab

    • ERC group
    • Leverage the genetic and epigenetic annotation of tumors to improve cancer prevention, diagnosis, prognosis and therapy
    • Apply cutting-edge genetic technologies and bioinformatics and integrate genomic data sets with clinical and fundamental biological information
    • To characterize how the tumor microenvironment influences tumor cells and determines response to cancer therapies
  • Claude Libert Lab

    • ​therapeutic potential of cytokines and their control mechanisms
    • matrix metalloproteinases (MMPs) and inflammation
    • determination of health status during aging
  • Adrian Liston Lab

    • ERC group
    • understanding the human immune system in health and during disease
    • biology of regulatory T cells
    • mechanisms of diabetes and development of new models for screening anti-diabetic drugs
  • Jean-Christophe Marine Lab

    • Melanoma biology and therapy resistance
    • Role of lncRNA in cancer
    • Disease modelling through mouse models (GEMM & PDX)
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