VIB scientists overview

Mouse

  • Stein Aerts Lab

    • ​cellular decision making and genome regulation
    • single-cell transcriptomics and epigenomics
    • systems biology of gene regulation
    • gene regulatory networks in the Drosophila brain and retina
    • high-throughput enhancer assays and computational enhancer models
  • Gabriele Bergers Lab

    • Functional irregulation of the tumor microenvironment and tumor cell compartment
    • Tumor niches and therapeutic resistance
    • Resistance to antiangiogenic therapy
    • Vascular and immunomodulation in cancer
  • Rudi Beyaert Lab

    • Protein-protein interactions, phosphorylation and ubiquitination
    • Cytokine, Toll-like receptor and T cell receptor signal transduction
    • NF-kappaB signaling in inflammation and cancer
    • Novel therapeutic targets and tools
  • Cédric Blanpain Lab*

    • ​embryonic development
    • stem cells and adult homeostasis
    • stem cells and tumor initiation
    • cancer stem cells
  • Vincent Bonin Lab

    • visual processing in the mammalian brain
    • ​network dynamics and computations
    • neural circuits and behavior
  • Peter Carmeliet Lab

    • ​Vascular metabolism & (lymph)angiogenesis
    • Omics analysis of healthy and diseased human and mouse endothelial/vascular cells to understand and target metabolic pathways
    • Therapeutic anti-angiogenesis: tumor vessel normalization (TVN)
    • Endothelial cell metabolic target discovery and drug development
  • Bart De Strooper Lab

    • ​Basic mechanisms of Alzheimer’s and Parkinson’s disease
    • Secretases of the amyloid peptide
    • Intramembrane proteolysis as a signaling mechanism
  • Joris de Wit Lab

    • ​molecular mechanisms of neuronal connectivity
    • role of cell adhesion molecules in synapse development and function
  • Dirk Elewaut Lab

    • ​Mucosal inflammation and its link to joint disease
    • Immune regulation in health and arthritic disease with focus on iNKT cells and Tregs
    • Cellular stress and lipid homeostasis during autoimmune disease
    • Biomechanical stress in arthritis
    • Cartilage and bone homeostasis in steady state and in arthritic disease
  • Sarah-Maria Fendt Lab

    • ​Cancer cells have a distinct metabolism adapted to their proliferative needs
    • Our focus is centered on understanding and targeting the differential metabolism of cancer cells
  • Bioinformatics Service Lab

    • ​​data analysis and interpretation of sequence data 
    • spatial and  single-cell transcriptomics
    • genomics - transcriptomics
  • Holger Gerhardt Lab

    • Importance of tip cell biology in vascular patterning, tumour angiogenesis and ischemic disease

     

  • Michele Giugliano Lab

    • Biophysics of computations in single neurons
    • Experimental investigations of dynamical response properties of cortical neurons
  • Rose Goodchild Lab

    • ​Molecular and cellular pathology of hereditary dystonias
    • Dystonia proteins in neurodevelopment
  • Martin Guilliams Lab

    • ​​Ontogeny of dendritic cells and macrophages
    • Functional characterization of dendritic cell and macrophage subsets across species and tissues in steady state and inflammation

  • Sebastian Haesler Lab

    • ​Reinforcement learning
    • Novelty response
    • Mesoscopic connectivity of neuromodulatory brain circuits
  • Bart Lambrecht and Hamida Hammad Lab

    • ​Study of the molecular mechanism of DC-epithelial interaction in asthma and how this is influenced by infection and environment.
    • Study how the unfolded protein response interferes with the functioning of cells in the immune system and how this might lead to lung disease.
  • Matthew Holt Lab

    • Basic mechanisms of signal transduction in astrocytes
    • Mechanisms of neuron-astrocyte interaction
    • Role of astrocytes in neuropathology
  • Markus Kleinewietfeld Lab

    • ​the immune cell balance as key regulator of human (auto)immune diseases
    • environmental factors in autoimmunity
    • plasticity of CD4+ T cells in health and disease
  • Fabian Kloosterman Lab

    • Functional and structural organization of memory circuits in the brain
    • Identification of the role of specific brain areas and cell types in memory processing
    • Use of high density electrode arrays to observe neuron-neuron communication in vivo
  • Bart Lambrecht and Hamida Hammad Lab

    • ​Study of the molecular mechanism of DC-epithelial interaction in asthma and how this is influenced by infection and environment.
    • Study how the unfolded protein response interferes with the functioning of cells in the immune system and how this might lead to lung disease.
  • Diether Lambrechts Lab

    • Leverage the genetic and epigenetic annotation of tumors to improve cancer prevention, diagnosis, prognosis and therapy
    • Apply cutting-edge genetic technologies and bioinformatics and integrate genomic data sets with clinical and fundamental biological information
    • To characterize how the tumor microenvironment influences tumor cells and determines response to cancer therapies
  • Mohamed Lamkanfi Lab

    • NOD-like receptor and inflammasome signaling networks,​ and their role in human disease
    • proteomics and genomics technologies for pathway discovery
  • Claude Libert Lab

    • ​therapeutic potential of cytokines and their control mechanisms
    • matrix metalloproteinases (MMPs) and inflammation
    • determination of health status during aging
  • Adrian Liston Lab

    • understanding the human immune system in health and during disease
    • biology of regulatory T cells
    • mechanisms of diabetes and development of new models for screening anti-diabetic drugs
  • Jean-Christophe Marine Lab

    • Melanoma biology and therapy resistance
    • Role of lncRNA in cancer
    • Disease modelling through mouse models (GEMM & PDX)
  • Stuart Maudsley Lab

    • Understanding complex and multifactorial neurodegenerative diseases by unraveling interaction networks of genes and proteins.
    • Generation of receptor-based therapeutic strategies to regulate pathological disease networks.
    • Development of novel bioinformatic tools for therapeutic design
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