VIB scientists overview

Cancer

  • Stein Aerts Lab

    • ERC group​
    • cellular decision making and genome regulation
    • single-cell transcriptomics and epigenomics
    • systems biology of gene regulation
    • gene regulatory networks in the Drosophila brain and retina
    • high-throughput enhancer assays and computational enhancer models
  • Gabriele Bergers Lab

    • Functional irregulation of the tumor microenvironment and tumor cell compartment
    • Tumor niches and therapeutic resistance
    • Resistance to antiangiogenic therapy
    • Vascular and immunomodulation in cancer
  • Cédric Blanpain Lab*

    • ​ERC group
    • embryonic development
    • stem cells and adult homeostasis
    • stem cells and tumor initiation
    • cancer stem cells
  • Peter Carmeliet Lab

    • ERC group​
    • Vascular metabolism & (lymph)angiogenesis
    • Omics analysis of healthy and diseased human and mouse endothelial/vascular cells to understand and target metabolic pathways
    • Therapeutic anti-angiogenesis: tumor vessel normalization (TVN)
    • Endothelial cell metabolic target discovery and drug development
  • Jan Cools Lab

    • ERC group
    • ​novel oncogenic mutations in leukemia
    • targeting deregulated pathways for leukemia therapy
    • cooperation of oncogenes during leukemogenesis
  • Sarah-Maria Fendt Lab

    • ERC group
    • Cancer cells have a distinct metabolism adapted to their proliferative needs
    • Our focus is centered on understanding and targeting the differential metabolism of cancer cells
  • Georg Halder Lab

    • ​Mechanisms that control organ growth, cancer and regeneration
    • Liver cancer and liver regeneration
    • The Hippo signaling pathway
    • Regenerative biology
    • Mouse and Drosophila genetics
  • Diether Lambrechts Lab

    • ERC group
    • Leverage the genetic and epigenetic annotation of tumors to improve cancer prevention, diagnosis, prognosis and therapy
    • Apply cutting-edge genetic technologies and bioinformatics and integrate genomic data sets with clinical and fundamental biological information
    • To characterize how the tumor microenvironment influences tumor cells and determines response to cancer therapies
  • Claude Libert Lab

    • ​therapeutic potential of cytokines and their control mechanisms
    • matrix metalloproteinases (MMPs) and inflammation
    • determination of health status during aging
  • Jean-Christophe Marine Lab

    • Melanoma biology and therapy resistance
    • Role of lncRNA in cancer
    • Disease modelling through mouse models (GEMM & PDX)
  • Massimiliano Mazzone Lab

    • ERC group
    • Genetic and molecular mechanisms regulating blood vessel formation
    • Influence of the microenvironment on macrophage phenotypes and positioning in the context of cancer and ischemia
    • Metabolic control of tumor immunity and resistance to immunotherapy
  • Joris Messens Lab

    • Study of the proteins and mechanisms that control redox homeostasis
    • Biochemical, structural and quantum chemical expertise in thiol/redox-chemistry
  • Anna Sablina Lab

    • ERC group
    • ​protein phosphatase complexes involved in control of cell transformation
    • models of cell transformation derived from manipulation of oncogenes and tumor suppressor genes
  • Massimo Santoro Lab

    • ERC group
    • identify new metabolic pathways important in vascular development, homeostasis and disease
    • study redox signaling and antioxidant response in endothelial cells
  • Jo Van Ginderachter Lab

    • ​myeloid cell heterogeneity and functions - functional genomics
    • Nanobodies against myeloid cell/inflammation markers
    • Tumor-host interactions
    • Trypanosome-host interactions
  • Peter Vandenabeele Lab

    • cell death modalities in vivo
    • in vivo focus on epithelial biology: skin and intestine
    • transgenic mouse models for caspases and RIP kinases