Proteins are some of the most fascinating and complex macromolecules in living systems that play extraordinarily diverse roles in sustaining life. These roles are mediated through the interactions that proteins make both with other proteins and with different molecular constituents of the cell.
The continuing focus of my research is on investigating the principles (structural, energetic and dynamic) that govern protein interactions. To that end I employ molecular simulation and modeling techniques to study protein-protein protein-DNA, and protein-ligand interactions at the atomic scale. I am furthermore keen on analyzing the properties of known protein structures and sequences in order to gain insight into how evolution has shaped the functional specificity of proteins.
In parallel to these molecular level investigations I am actively engaged in developing quantitative and integrative computational approaches for analyzing physical and functional interactions between proteins, protein complexes and biochemical pathways at the cellular level.
My research activities closely combine the development of analysis methods and software tools, with their application to important biological problems with relevance to human health.
Interaction landscape of membrane-protein complexes in Saccharomyces cerevisiaeBabu M, Vlasblom J, Pu S, Guo X, Graham C, Bean B, Burston H, Vizeacoumar F, Snider J, Phanse S, Fong V, Tam Y, Davey M, Hnatshak O, Bajaj N, Chandran S, Punna T, Christopolous C, Wong V, Yu A, Zhong G, Li J, Stagljar I, Conibear E, Wodak S, Emili A, Greenblatt JNATURE, 489, 585-9, 2012
PhD: Columbia University, New York, USA, 1974
Postdoc: Columbia University, New York, USA
Postdoc: ULB, Brussels, Belgium
PI: EBI-EMBL, Hinxton, UK, 1995-2002
PI: Hospital for Sick Children, Toronto, Canada, 2004-12
Prof: University of Toronto, Canada, 2013-present
Co-Director: Centre of Structural Biology & Bioinformatics, ULB, Belgium
Visiting Group leader VIB since February 2014