Shoshana Wodak Lab

Research focus

​Proteins are some of the most fascinating and complex macromolecules in living systems that play extraordinarily diverse roles in sustaining life. These roles are mediated through the interactions that proteins make both with other proteins and with different molecular constituents of the cell.
The continuing focus of my research is on investigating the principles (structural, energetic and dynamic) that govern protein interactions. To that end I employ molecular simulation and modeling techniques to study protein-protein protein-DNA, and protein-ligand interactions at the atomic scale. I am furthermore keen on analyzing the properties of known protein structures and sequences in order to gain insight into how evolution has shaped the functional specificity of proteins.
In parallel to these molecular level investigations I am actively engaged in developing quantitative and integrative computational approaches for analyzing physical and functional interactions between proteins, protein complexes and biochemical pathways at the cellular level.
My research activities closely combine the development of analysis methods and software tools, with their application to important biological problems with relevance to human health.

Publications

The Balancing Act of Intrinsically Disordered Proteins: Enabling Functional Diversity while Minimizing PromiscuityMacossay Castillo M* Marvelli G Guha Roy M Jain A Kihara D Tompa P Wodak S*JOURNAL OF MOLECULAR BIOLOGY, 431, 1650-1670, 2019* or °: authors contributed equally
Allostery in Its Many Disguises: From Theory to Applications.Wodak Shoshana Paci Emanuele Dokholyan Nikolay Berezovsky Igor Horovitz Amnon Li Jing Hilser Vincent Bahar Ivet Karanicolas John Stock Gerhard Hamm Peter Stote Roland Eberhardt Jerome Chebaro Yassmine Dejaegere Annick Cecchini Marco Changeux Jean-Pierre Bolhuis Peter Vreede Jocelyne Faccioli Pietro Orioli Simone Ravasio Riccardo Yan Le Brito Carolina Wyart Matthieu Gkeka Paraskevi Rivalta Ivan Palermo Giulia McCammon J Andrew Panecka-Hofman Joanna Wade Rebecca Di Pizio Antonella Niv Masha Nussinov Ruth Tsai Chung-Jung Jang Hyunbum Padhorny Dzmitry Kozakov Dima McLeish TomSTRUCTURE, 27, 566-578, 2019
Interplay of self-association and conformational flexibility in regulating protein function.Garton Michael MacKinnon Stephen Malevanets Anatoly Wodak ShoshanaPHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 373, , 2018
Interplay of buried histidine protonation and protein stability in prion misfolding.Malevanets Anatoly Chong P Andrew Hansen D Flemming Rizk Paul Sun Yulong Lin Hong Muhandiram Ranjith Chakrabartty Avi Kay Lewis Forman-Kay Julie Wodak ShoshanaScientific Reports, 7, 882, 2017
Modeling protein-protein and protein-peptide complexes: CAPRI 6th edition.Lensink Marc Velankar Sameer Wodak ShoshanaPROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 85, 359-377, 2017

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Shoshana Wodak

Shoshana Wodak

Research area(s)

Bio

PhD: Columbia University, New York, USA, 1974
Postdoc: Columbia University, New York, USA
Postdoc: ULB, Brussels, Belgium
PI: EBI-EMBL, Hinxton, UK, 1995-2002
PI: Hospital for Sick Children, Toronto, Canada, 2004-12
Prof: University of Toronto, Canada, 2004-2012
Co-Director: Centre for Structural Biology & Bioinformatics, ULB, Brussels (1995-2004)
Elected member of EMBO 1990
Head of the Management Committee of CAPRI (Critical Assessment of Predicted Interactions) (www.capri-docking.org) since 2013
Fellow of the ISCB (International Society for Computational Biology), 2016
Member of the Elixir 3DBioinfo Community Executive Committee, 2019
Visiting Group Leader VIB since February 2014​

Contact Info

VIB-VUB Center for Structural BiologyBuilding EPleinlaan 2 1050 BRUSSELRoute description