Light Microscopy Lab

Research focus

Our research focuses on the biophysical properties of cell signaling, concerning both the dynamical changes over time and the spatial location of cell signals. To this aim, new methods to construct topographical maps of the cellular membrane and measure lipid and signaling molecules distributions are explored. Also novel ways to perform quantitative localization measurements are investigated. Recently spatial statistics is employed to link between observation and modeling. More in detail I investigate how cell membrane molecules are distributed and how their distribution changes over time. This is especially interesting as during development, aging and for the characterization of neurodegenerative diseases, where disease linked proteins get misrouted leading to the well-known pathologies. ​​​​

Publications

Inhomogeneity Based Characterization of Distribution Patterns on the Plasma MembranePaparelli L Corthout N Pavie B Wakefield D Sannerud R Jovanovic-Talisman T Annaert W* Munck S*PLoS Computational Biology, 12, e1005095, 2016* These authors contributed equally
Analyzing Protein Clusters on the Plasma Membrane: Application of Spatial Statistical Analysis Methods on Super-Resolution Microscopy ImagesPaparelli L, Corthout N, Pavie B, Annaert W, Munck SADVANCES IN ANATOMY EMBRYOLOGY AND CELL BIOLOGY, 219, 95-122, 2016
HDAC6 Is a Bruchpilot Deacetylase that Facilitates Neurotransmitter ReleaseMiskiewicz K, Jose L, Yeshaw W, Valadas J, Swerts J, Munck S, Feiguin F, Dermaut B, Verstreken PCell Reports, 8, 94-102, 2014
Sub-diffraction imaging on standard microscopes through photobleaching microscopy with non-linear processingMunck S, Miskiewicz K, Sannerud R, Menchon S, Jose L, Heintzmann R, Verstreken P, Annaert WJOURNAL OF CELL SCIENCE, 125, 2257-66, 2012
Cytokinesis remnants define first neuronal asymmetry in vivoPollarolo G, Schulz J, Munck S, Dotti CNATURE NEUROSCIENCE, 14, 1525-33, 2011

Job openings

Sebastian Munck

Sebastian Munck

Research area(s)

Model organism(s)

Bio

PhD: BioImaging Center Ludwig-Maximilians-University München, Germany 2003
Product Manager: Till Photonics, Germany, 2003-04
Postdoc: Medical University Innsbruck, Austria, 2004-06
VIB Staff Scientist 2006-2012
VIB Expert Technologist since 2013
Part-time Assistant Professor Fac. of Medicine as of October 2015​​​

Contact Info

VIB-KU Leuven Center for Brain & Disease ResearchO&N 4, 6e verdCampus GasthuisbergHerestraat 49, bus 602 3000 LEUVENRoute description