Sebastian Haesler Lab

Research focus

​The long-term goal of our lab is to understand how animals learn from experience and how they subsequently use this knowledge to guide behavior. One form of learning, commonly observed in humans and animals, relies on the reinforcing effect of rewarding or aversive experience. As a result of such learning, sensory cues, behavioral responses or specific actions become associated with positive or negative values, which is critical for seeking resources and avoiding danger.

In a dynamically changing environment it is also important to identify the boundaries of current knowledge, in order to initiate new learning whenever necessary. Consistent with this idea, humans and animals are capable of rapidly detecting novelty, taking as little as 85ms in humans. Novel stimuli trigger distinct orienting and exploratory behaviors, which habituate after only a few exposures, suggesting a very rapid form of memory formation. Moreover, animal learning theories postulate that the rate of learning depends on the degree to which rewards or punishments are novel, thus also highlighting the importance of novelty for learning.

Research in our lab focuses on the neural mechanisms underlying the two problems described above: 

  1. What circuit computations are involved in learning from reward and punishment? 
  2. What are the mechanisms for novelty detection and behavioral novelty responses?

Previous studies have identified key brain areas and neuromodulatory systems involved in reinforcement learning and novelty processing. However, a mechanistic description of how different neurons, interacting dynamically within local and larger scale circuits, mediate learning and generate behavioral responses is currently lacking. We approach this problem using a combination of multielectrode recording and optogenetic techniques in awake, behaving mice. By genetically tagging specific neuronal populations for electrophysiological identification and manipulation, this approach allows for the precise characterization of the firing properties of defined neuron types and for testing the causal contribution of their firing for specific aspects of behavior. By complementing this approach with anatomical circuit mapping using viral tracing tools, we aim at revealing some of the neural computations involved in learning and decision making.

Disturbances in reinforcement learning and novelty processing have been linked to human pathological conditions including schizophrenia, depression and autism, as well as human personality traits associated with maladaptive behaviors such as addiction. Therefore, our research program also has implications for understanding these mental diseases and may ultimately support the development of novel interventional strategies.

> video on basic research on nanotech meets biotech - Sebastian Haesler - ©VIB, 2015

Publications

Spontaneous Rapid Odor Source Localization Behavior Requires Interhemispheric CommunicationEsquivelzeta Rabell J, Mutlu A, Martin del Olmo PCURRENT BIOLOGY, 27, 1542-1548 e4, 2017
Neurotechnology and Society: Strengthening Responsible Innovation in Brain ScienceGarden H, Bowman D, Winickoff DNEURON, 92, 642-646, 2016
Neuron-type-specific signals for reward and punishment in the ventral tegmental areaCohen J, Vong L, Lowell B, Uchida NNATURE, 482, 85-8, 2012
Incomplete and inaccurate vocal imitation after knockdown of FoxP2 in songbird basal ganglia nucleus Area XHaesler S, Rochefort C, Georgi B, Licznerski P, Osten P, Scharff CPLOS BIOLOGY, 5, e321, 2007
An evolutionary perspective on FoxP2: strictly for the birds?Scharff C, Haesler SCURRENT OPINION IN NEUROBIOLOGY, 15, 694-703, 2005

Job openings

News

Researchers discover mechanism behind rapid smell source localization

22/05/2017 - Scientists at NERF have provided fundamental insights into mechanism of smell localization. This marks an important step in unraveling the entire neural odor localization mechanism, which is highly valuable to the study of memory diseases.

NERF symposium 2013

22/02/2013 - The second edition of NERF's annual neurotechnology symposium will focus on large scale approaches/technologies for studying neural circuits, neuromorphics and brain machine interfaces

NERF - where biotech and micro-electronics meet

14/12/2012 - In 2009 IMEC, KU Leuven and VIB set up a joint basic research initiative Neuro-Electronics Research Flanders (NERF) whose main mission is to unravel the function of brain circuits.

Imec, VIB and K.U.Leuven join forces in pioneering brain research at NERF and in the Human Brain Project

15/05/2011 - Today, Flanders' ambitious brain research that may lead to better diagnosis and treatment of brain disease, new prosthesis technologies for patients with a disability, a new generation of more intelligent robots, etc. switches into higher gear.

Sebastian Haesler

Sebastian Haesler

Research area(s)

Model organism(s)

Bio

​PhD: Max Planck Institute for Molecular Genetics, Germany, '01-'06
Postdoc: Harvard University, US, '07-'12
VIB Group Leader since 2012

Contact Info

NERFImecImec CampusKapeldreef 75 3001 LEUVENRoute description