The major research goal in our laboratory is to understand the mechanisms controlling the development and evolution of the cerebral cortex, from stem cells to neuronal networks, from mouse to man.
The cerebral cortex is one of the most complex and important structures in our brain. In correlation with its elaborate functions, it is characterized by a huge diversity of neuronal identities, each cortical neuron displaying specific patterns of gene expression and synaptic connectivity. The mechanisms of formation of cortical networks have direct relevance to several diseases, such as epilepsy, autism, and mental disorders, as well as for the development of rationally designed cell therapies for neurological conditions such as Alzheimer’s disease or stroke.
A first set of projects is centered on the mouse model, where we combine molecular and cellular approaches to study intrinsic and extrinsic factors in cortical development, both in vivo (using mouse transgenesis and in utero electroporation) and in vitro (using organotypic assays).
In a second set of projects centered on human embryonic stem (ES), and induced pluripotent stem (iPS) cells, we use innovative models to study human cortex development as well as neurodegenerative diseases.
In a third set of projects centered on human cortex development, we try to identify and study the function of genes that may link the development and evolution of human-specific features in our brain.
Pierre Vanderhaeghen is a visiting PI to the VIB Center for the Biology of Diseases, where he shares his expertise on stem cell technology.
Please refer to Pierre Vanderhaeghen's own website (menu at the right) for the full overview of his research at ULB.
Pyramidal neurons derived from human pluripotent stem cells integrate efficiently into mouse brain circuits in vivoEspuny-Camacho I, Michelsen K, Gall D, Linaro D, Hasche A, Bonnefont J, Bali C, Orduz D, Bilheu A, Herpoel A, Lambert N, Gaspard N, Peron S, Schiffmann S, Giugliano M, Gaillard A, Vanderhaeghen PNEURON, 77, 440-56, 2013 Ephrin-B1 controls the columnar distribution of cortical pyramidal neurons by restricting their tangential migrationDimidschstein J, Passante L, Dufour A, Van Den Ameele J, Tiberi L, Hrechdakian T, Adams r, Klein R, Lie D, Jossin Y, Vanderhaeghen PNEURON, 79, 1123-35, 2013 BCL6 controls neurogenesis through Sirt1-dependent epigenetic repression of selective Notch targetsTiberi L, Van Den Ameele J, Dimidschstein J, Piccirilli J, Gall D, Herpoel A, Bilheu A, Bonnefont J, Iacovino M, Kyba M, Bouschet T, Vanderhaeghen PNATURE NEUROSCIENCE, 15, 1627-35, 2012 An intrinsic mechanism of corticogenesis from embryonic stem cellsGaspard N, Bouschet T, Hourez R, Dimidschstein J, Naeije G, Van Den Ameele J, Espuny-Camacho I, Herpoel A, Passante L, Schiffmann S, Gaillard A, Vanderhaeghen PNATURE, 455, 351-7, 2008 Ephrin signalling controls brain size by regulating apoptosis of neural progenitorsDepaepe V, Suarez-Gonzalez N, Dufour A, Passante L, Gorski J, Jones K, Ledent C, Vanderhaeghen PNATURE, 435, 1244-50, 2005
PhD: Université Libre de Bruxelles (ULB), Brussels, Belgium, 1996
Postdoctoral Fellow: Harvard Medical School, Boston, USA, 1996-2000
Professor: IRIBHM and ULB Neuroscience Inst., ULB, Brussels, Belgium
Visiting Group leader VIB since January 2013