Moritz Nowack Lab

Research focus

​Programmed cell death (PCD) is a fundamental biological process denoting the genetically encoded, actively controlled suicide of a cell. PCD had its evolutionary origins already billions of years ago in bacteria that defended their clonal colonies against viral attacks by sacrificing individual cells for the greater good of the colony. With the evolution of complex multicellular organisms, PCD has adopted a multitude of functions in physiological and pathological development. In both animals and plants defects in the molecular control of PCD can cause severe developmental aberrations and diseases.

The significance of PCD for human health has been recognized decades ago, and today we have a detailed understanding of the molecular regulation of apoptosis and some other forms of animal PCD. In plants however, we still know comparatively little about PCD – despite the fact that different forms of PCD occur throughout plant life, and many of them are critical for plant health and fitness, as well as for successful growth and reproduction.
 
Our lab is interested in the molecular control of plant PCD during vegetative and reproductive development. Dozens of different cell types, tissues, and organs execute a tightly regulated, actively controlled cell death in the course of their differentiation and development. We identified several commonly expressed plant cell death markers, suggesting that a conserved PCD core machinery controls initiation and execution of cell death in diverse developmental contexts.

Using cutting edge molecular-, cell- and systems-biology approaches, we are unravelling the mechanisms that control preparation, initiation and execution of plant PCD as an inherent part of cellular differentiation. Most research is performed in the framework of vegetative and reproductive development of the model plant Arabidopsis thaliana, but additionally, we investigate PCD during fertilization and seed set of maize (Zea mays) as an important seed-producing crop plant.

Publications

Mechanisms of developmentally controlled cell death in plantsVan Durme M, Nowack MCURRENT OPINION IN PLANT BIOLOGY, 29, 29-37, 2016
Only in dying, life: programmed cell death during plant developmentVan Hautegem T, Waters A, Goodrich J, Nowack MTRENDS IN PLANT SCIENCE, 20, 102-113, 2015
A Conserved Core of Programmed Cell Death Indicator Genes Discriminates Developmentally and Environmentally Induced Programmed Cell Death in PlantsOlvera Carrillo Y, Van Bel M, Van Hautegem T, Fendrych M, Huysmans M, Simaskova M, Van Durme M, Buscaill P, Rivas S, Coll N, Coppens F, Maere S, Nowack MPLANT PHYSIOLOGY, 169, 2684-99, 2015
The root cap: a short story of life and deathKumpf R, Nowack MJOURNAL OF EXPERIMENTAL BOTANY, 66, 5651-62, 2015
Programmed Cell Death Controlled by ANAC033/SOMBRERO Determines Root Cap Organ Size in ArabidopsisFendrych M, Van Hautegem T, Van Durme M, Olvera-Carrillo Y, Huysmans M, Karimi M, Lippens S, Guerin C, Krebs M, Schumacher K, Nowack MCURRENT BIOLOGY, 24, 931-40, 2014
Moritz Nowack

Moritz Nowack

Research area(s)

Model organism(s)

Bio

​​PhD: Univ of Cologne, Cologne, Germany, 2007
Postdoc.: Max Planck Institute for Plant Breeding Research, Cologne, Germany, 2007-09
VIB Group leader as of October 2009

Contact Info

VIB-UGent Center for Plant Systems biologyUGent-VIB Research Building FSVMTechnologiepark 927 9052 GENTRoute description