Markus Kleinewietfeld Lab

Research focus

​We are interested in mechanisms of how immune system imbalance leads to human disease. Our group focuses on the role of specific immune cell subsets in this process, in particular on the interplay of anti-inflammatory CD4+ regulatory T cells and pro-inflammatory CD4+ effector T cells. Here, our major interest lies in the understanding of the processes that lead to autoimmune diseases like multiple sclerosis (MS) or are related to metabolic- and cardiovascular diseases and cancer. To study these processes, we use a translational approach, combining the analysis of human samples and the use of experimental model systems by various immunological and molecular biology state-of-the-art techniques.

Currently we focus on the following topics:
a) Environmental factors influencing the immune cell balance and disease (nutrition, microbiota) (for overview:  Manzel et al., Curr Allergy Asthma Rep. 2014, Binger et al., Pflugers Arch. 2015, Jörg et al., Cell Mol Life Sci. 2016)
b) Plasticity of T cell subsets in health and disease (for overview: Kleinewietfeld et al., Semin Immunol. 2013 Nov & Immunol Rev. 2014)

Publications

Genetic and epigenetic fine mapping of causal autoimmune disease variantsFarh K, Marson A, Zhu J, Kleinewietfeld M, Housley W, Beik S, Shoresh N, Whitton H, Ryan R, Shishkin A, Hatan M, Carrasco-Alfonso M, Mayer D, Luckey C, Patsopoulos N, De Jager P, Kuchroo V, Epstein C, Daly M, Hafler D, Bernstein BNATURE, 518, 337-43, 2015
Regulatory T cells in autoimmune neuroinflammationKleinewietfeld M, Hafler DIMMUNOLOGICAL REVIEWS, 259, 231-44, 2014
Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cellsKleinewietfeld M, Manzel A, Titze J, Kvakan H, Yosef N, Linker R, Muller D, Hafler DNATURE, 496, 518-22, 2013
Microbial reprogramming inhibits Western diet-associated obesityPoutahidis T, Kleinewietfeld M, Smillie C, Levkovich T, Perrotta A, Bhela S, Varian B, Ibrahim Y, Lakritz J, Kearney S, Chatzigiagkos A, Hafler D, Alm E, Erdman SPLoS One, 8, e68596, 2013
Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppressionBorsellino G, Kleinewietfeld M, Di Mitri D, Sternjak A, Diamantini A, Giometto R, Hopner S, Centonze D, Bernardi G, Dell'acqua M, Rossini P, Battistini L, Rotzschke O, Falk KBLOOD, 110, 1225-32, 2007

Job openings

News

Nils-ilja-richter award 2015 goes to Markus Kleinewietfeld

05/04/2016 - ​The German Society for Autoimmune Diseases (Deutsche Gesellschaft für Autoimmunerkrankungen e.V., DGfAE) has presented the 2015 Nils-Ilja-Richter Award to Markus Kleinewietfeld(VIB/UHasselt).

VIB starts up a research group on multiple sclerosis at UHasselt

24/11/2015 - The VIB/UHasselt Kleinewietfeld Lab was officially opened. This research group is led by Prof. Markus Kleinewietfeld, he was appointed through an international selection process to further expand on his MS research at VIB and the Hasselt University.

Markus Kleinewietfeld

Markus Kleinewietfeld

Research area(s)

Model organism(s)

Bio

PhD: Max-Delbrück Ctr for Mol Med & Free Univ. Berlin, Germany, 2006
Postdoc: Max-Delbrück Ctr for Mol Med, Berlin, Germany, 2006-09, Harvard Medical School, Boston, USA, 2009-10 and Broad Inst. MIT & Harvard Univ., Cambridge, USA, 2009-14
Associate Research Scientist: Yale School of Med, New Haven, USA, 2010-13
Group leader: Technische Universität Dresden, Germany, 2013-15

VIB group leader and Associate Professor at UHasselt since November 2015.

Contact Info

VIB Center for Inflammation ResearchHasselt UniversityAgoralaan bus C 3590 DIEPENBEEK