Lynette Lim Lab

Research focus

Information processing in the brain depends on specialized circuits that are formed by distinct types of neurons. How these different nerve cells emerge and mature during development remains a fundamental question in neurobiology. We are interested to define at single-cell resolution the metabolic and transcriptomic programmes that shape neuronal diversity and circuit assembly in the developing mammalian cortex. 

Our research focuses primarily on GABAergic cortical neurons since they are one of the most diverse cell types in the brain and play multifaceted roles in controlling principal pyramidal neurons and fine-tune network computation. We employ an interdisciplinary approach to our work that combines mouse genetics, virus tracing, cell fate-mapping, metabolomics, and single-cell RNA sequencing, with cutting-edge imaging techniques and bioinformatics to define how developmental programmes influence cortical circuit formation.

Job openings


International top talents join Leuven neuroscience research community

23/08/2019 - ​The VIB-KU Leuven Center for Brain & Disease Research has attracted two new faculty members. Sandrine Da Cruz will lead a laboratory focusing on the mechanisms of ALS, Lynette Lim will lead a group focusing on the development of neuronal circuits.

Lynette Lim

Lynette Lim

Research area(s)

Model organism(s)


PhD: National University of Singapore, Singapore, 2007
Post-doc: Institute of Neuroscience, Alicante, Spain, 2012-2014 , King’s College London, UK, 2014-2019
VIB Group Leader since January 1, 2020

Contact Info

VIB-KU Leuven Center for Brain & Disease ResearchO&N 4, 6e verdCampus GasthuisbergHerestraat 49, bus 602 3000 LEUVENRoute description