Kevin Verstrepen Lab

Research focus

​Some properties of living organisms evolve and diverge at a much higher pace than other traits. Examples range from the molecular composition of the microbial cell surface to the skeletal morphology of dogs. The research of the VIB Laboratory of Systems Biology, K.U.Leuven shows that the mechanisms underlying hyper-evolvable properties often lie at the border between genetics and epigenetics, including such phenomena as chromatin silencing, hyper-variable tandem repeats, transposable elements, telomeric recombination, and hysteresis in regulatory pathways. Hence, one of the primary focuses of the lab is to study these processes, using classic genetic techniques as well as genomics, bioinformatics and mathematical modeling.

It is interesting to note that swift evolution can be seen as a mechanism for “short-term transgenerational memory”. In other words, parental cells can pass on certain information to their progeny, but only for a few generations. In this way, the “memory” stays flexible enough to deal with rapid (external) changes that might require cells to “ignore” the parental “advice”. Hence, we hypothesize that the genetic systems underlying hyper-evolvable traits often developed as a response to hyper-variable selective pressure. This implies that apart from standard genetics and biochemistry, we also incorporate evolution theory to help explain and understand our results.

We focus primarily on the model eukaryote Saccharomyces cerevisiae, although we are also exploring other organisms, often in collaboration with other groups.

In particular, the lab currently focuses on three related topics:

  • Telomeres (i.e. the end of chromosomes) are some of the most dynamic and unstable regions in genomes. We study a S. cerevisiae gene family located near the telomeres to investigate how their unique location allows the genes to evolve much more quickly and benefit from both genetic and epigenetic inheritance to coordinate their regulation. Such mechanisms may allow parental cells to pass on information about recent growth conditions to their progeny. Stochastic silencing and desilencing of the telomeric genes allow some cells to “escape” this epigenetic regulation and explore alternative lifestyles.
  • Yeast cells show an amazing capacity to adhere to various abiotic surfaces, as well as other living cells. However, closely related strains vary widely in their adherence phenotypes. Our research shows that this swift evolution is explained by the fact that the genes underlying adherence contain internal tandem repeat sequences. These repeats are unstable and generate frequent mutation events, leading to altered adherence phenotypes. This might allow pathogens to adhere to novel materials used in today’s medical devices. Moreover, since the variable adhesion proteins are located at the cell surface, the mechanism may also allow cells to elude the host’s immune system. 
  • Building on the previous project, we are launching a genome-wide survey to investigate how important tandem repeats are as drivers of genetic changes in genomes. We hypothesize that tandem repeats function as hyper-variable genetic modules that confer swift evolution of both coding and regulatory regions. As such, tandem repeats may represent a common but much ignored mechanism of genetic change, besides the much more widely studied single nucleotide polymorphisms (SNPs) and copy number variations (CNVs). Using the S. cerevisiae genome as a model, we use comparative genomics and genetic engineering to explore the physiological role of all tandem repeats in the yeast genome. In addition, through various collaborations, we also explore the importance of repeats in other organisms, including pathogens, plants and humans.


Domestication and Divergence of Saccharomyces cerevisiae Beer YeastsGallone B* Steensels J* Prahl T Soriaga L Saels V Herrera B Merlevede A Roncoroni M Voordeckers K Miraglia L Teiling C Steffy B Taylor M Schwartz A Richardson T White C Baele G Maere S* Verstrepen K*CELL, 166, 1397-1410, 2016* These authors contributed equally
Variable Glutamine-Rich Repeats Modulate Transcription Factor ActivityGemayel R, Chavali S, Pugach K, Legendre M, Zhu B, Boeynaems S, van der Zande E, Gevaert K, Rousseau F, Schymkowitz J, Babu M, Verstrepen KMOLECULAR CELL, 59, 615-627, 2015
Taming wild yeast: potential of conventional and nonconventional yeasts in industrial fermentationsSteensels J, Verstrepen KAnnual Review of Microbiology, 68, 61-80, 2014
Duplication of a promiscuous transcription factor drives the emergence of a new regulatory networkPugach K, Voet A, Kondrashov F, Voordeckers K, Christiaens J, Baying B, Benes V, Sakai R, Aerts J, Zhu B, Van Dijck P, Verstrepen KNature Communications, 5, 4868, 2014
Different levels of catabolite repression optimize growth in stable and variable environmentsNew A, Cerulus B, Govers S, Perez-Samper G, Zhu B, Boogmans S, Xavier J, Verstrepen KPLOS BIOLOGY, 12, e1001764, 2014

Job openings


KU Leuven and VIB open an experimental brewery

27/10/2017 - ​Professor Kevin Verstrepen (VIB-KU Leuven) and his research group are starting an experimental brewery at the Kasteelpark in Arenberg (Heverlee). Professor Verstrepen’s team is known across the globe for its research into yeast.

Beer yeasts are dogs, wine yeasts are cats

08/09/2016 - Researchers from VIB, KU Leuven and Ghent University found that yeasts used for beer and winemaking have been domesticated in the 16th century, around 100 years before the discovery of microbes.

Important role of nucleocytoplasmic transport in amyotrophic lateral sclerosis and frontotemporal dementia

12/02/2016 - Moreover, these insights have a solid basis, since they come from 4 different scientific angles. It is an important next step in our understanding of these terrible diseases.”

New Diversity for Lager Beers

25/09/2015 - Unlike ales, lager beers differ little in flavor. But now, by creating new crosses among the relevant yeasts, Kevin Verstrepen, PhD, Stijn Mertens, and their collaborators at VIB/KU Leuven have opened up new horizons of taste.

Polyglutamine repeats play key role in functional development of cells

11/08/2015 - Scientists at VIB and KU Leuven have revealed that variable polyglutamine repeats in the DNA tune the function of the protein in which they reside. To date, these repeats were known only to cause severe neurodegenerative diseases such as Huntington’s.

Barry Callebaut, VIB and KU Leuven optimize cocoa fermentation process

12/03/2015 - ​Inspired by Belgian beer brewers: Newly developed yeast helps make chocolate more delicious

Scientists reveal why beer tastes good to us and to flies!

09/10/2014 - ​Beer yeasts produce chemicals that mimic the aroma of fruits in order to attract flies that can transport the yeast cells to new niches, report scientists from VIB, KU Leuven and NERF in the reputed journal Cell Reports.

Reconstruction of prehistoric DNA refutes criticism on theory of evolution

11/12/2012 - Scientists from VIB, KU Leuven, UGent and Harvard have succeeded in reconstructing DNA and proteins from prehistoric yeast cells.

VIB-BGI Genomics meeting (15 February 2012) - Registrations closed

05/01/2012 - VIB and BGI are organising a genomics meeting on 15 Feb 2012 in Leuven, Belgium. Executives and investigators from both institutions will share their expertise on large scale genomcs and computational analysis

VIB-K.U.Leuven scientist Kevin Verstrepen develops a tailor-made yeast for beer with more flavour

19/01/2011 - “We want you to create a strain of yeast for a very special kind of beer. It has to have a lot character, but it shouldn't be too heavy.” This was beer brewer Bart Landuyt's assignment for the lab of Kevin Verstrepen, one of VIB's yeast specialists.

VIB-K.U.Leuven scientist Kevin Verstrepen elected EMBO Young Investigator

17/12/2010 - Kevin Verstrepen of VIB-K.U.Leuven has been selected by the European Molecular Biology Organization (EMBO) to receive support from the Young Investigator Programme.

VIB-K.U.Leuven scientists unravel the evolutionary process of beer and wine production

14/05/2010 - ​The ability of yeast cells to convert sugar to alcohol, the key process in the production of beer and wine, can be attributed to a remarkable evolutionary process.

Saved by junk DNA

29/05/2009 - VIB researchers linked to K.U.Leuven and Harvard University show that stretches of DNA previously believed to be useless ‘junk’ DNA play a vital role in the evolution of our genome.

Kevin Verstrepen

Kevin Verstrepen

Research area(s)

Model organism(s)


​PhD: Univ. of Leuven, Leuven, Belgium, 2003
Postdoc: MIT, Whitehead Inst. for Biomedical Research, Cambridge, US, 2003-05
Group leader: FAS Ctr. for Systems Biology, Harvard Univ., Cambridge, US, 2005-08
VIB Group leader since 2009
VIB Science Director since 2017

Contact Info

VIB-KU Leuven Center for MicrobiologyBioincubatorGaston Geenslaan 1 bus 2471 3001 HEVERLEE