Karolien De Bosscher Lab

Research focus

 
MISSION STATEMENT

Translational: Basic scientific research with a focus on novel anti-inflammatory therapies (to circumvent side effects), novel anti-cancer treatments (to overcome resistance and side effects) and the development of advanced GR-tailored drug screening platforms.

Nuclear Receptor: Focus on nuclear receptor family members GR, MR, PPAR and ERR as individual drug 
targets and their crosstalk mechanisms. These NRs (signaling and transcriptional mechanisms) are studied in-depth on a biomolecular level.

Research: Combining dry and wet lab experiments to validate fundamental
insights in biologically/clinically relevant settings.
Expertise with cell-based anti-inflammatory drug.
Screening platforms.

Currently, corticosteroids in the clinic are too often used with a “one-size-fits-all” rationale for the treatment/management of inflammatory diseases, metabolic disorders and cancer.
Glucocorticoid receptor 
(GR) regulation and responses are far more complex than previously recognized. 
GR is not a “one-size-fits-all” type of target, but requires a tailored approach when it comes to drug discovery to meet the correct insight that
GR is a receptor demonstrating a high degree of plasticity. Multiple GR conformations must exist, likely resulting in different anti-inflammatory (AI) profiles. Trying to achieve a selective GR-mediated activation of particular AI profiles may offer the potential for the development of safer and disease-tailored GR-targeting medicines.

(Figure 1: Desmet and De Bosscher, J Clin Invest. 2017;127(4):1136-1145)

A better selectivity may be reached either by GR ligand screenings/rational drug design (classic approach) or by exploiting opportunities that arise from the recent recognition that several NRs interact physically and functionally with different members of the NR family (our original approach). 

We hypothesize that a re-wiring of nuclear receptor cross-talk mechanisms towards unconventional,but favorable, nuclear receptor heterodimers may influence gene expression patterns such that enhanced therapeutic benefit may be within reach. 

The latter phenomena allow for the development of novel ligands with affinity for, and (anta)agonism for, both NR partners. The fields of application of our strategies range from chronic inflammatory and metabolic disorders to drug repurposing strategies in cancer.  

 
 
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Karolien De Bosscher

Karolien De Bosscher

Research area(s)

Model organism(s)

Bio

PhD: UGent, Department Molecular and Biomedical Research, Faculty of Sciences, 2000
Postdoctoral Fellow: Cancer Research UK, London (UK), 2000-2002                                                
Postdoctoral Fellow/junior group leader: FWO-Vlaanderen, UGent (Belgium), 2002-2013
Research professor (BOF-ZAP): UGent, Department Biochemistry, Faculty of Medicine, 2013-2018
Full professor: UGent, Department Biomolecular Medicine, Faculty of Medicine, 2018-..
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Short research stays abroad:
2007 - Bilateral FWO-Vlaanderen supported exchange program University of Buenos Aires 
2005 - Bilateral FWO-Vlaanderen supported exchange program University of Stellenbosch

Contact Info

VIB-UGent Center for Medical BiotechnologyAlbert Baertsoenkaai 3 9000 GENTRoute description