> Lees de Nederlandstalige beschrijving van het onderzoek van Jeroen Raes (in Dutch)
The functioning of the human body constitutes a complex interplay of human processes and “services” rendered to us by the 1,000 trillion microbial cells we carry. Disruption of this natural microbial flora is linked to infection, autoimmune diseases and cancer, but detailed knowledge about our microbial component remains scarce. Recent technological advances such as metagenomics and next-generation sequencing make it possible, for the first time, to study the various microbiota of the human body at a previously unseen scale. These advances have allowed the initiation of the International Human Microbiome Project, aiming at genomically characterizing the totality of human-associated micro-organisms (the “microbiome”).
However, the complexity of metagenomic datasets makes their analysis a major bottleneck. This allowed the birth of a new, exciting subfield in computational biology which will eventually allow classical, cellular-level systems biology to progress towards modeling entire communities (“ecosystems biology”) and untangling interspecies networks of competition, collaboration and communication at the molecular level.
The Raes lab combines large-scale, next-generation sequencing with novel computational approaches to investigate the functioning and variability of the healthy human microbiome at the systems level and study its alteration in disease. In this context, we recently discovered the existence of discrete gut flora types (enterotypes), that are independent of host properties such as nationality, sex or race and are studying the predictive power of microbial markers for various intestinal diseases. In addition, we focus on the development of computational methods for the analysis of (next-generation) sequence data and the investigation of community properties from metagenomics, metatranscriptomics and meta-metabolomics data, which are applied in a wide range of environments (ocean, soil, etc.).
The links below cover Jeroen Raes' latest press release 'People fall into three categories of gut microbiota, metagenomics study shows'
Read also the survey in the recent Nature Biotechnology issue:
'Jeroen Raes is one of the leading scientists that have garnered momentum in microbiome research'
Inflammation-associated enterotypes, host genotype, cage and inter-individual effects drive gut microbiota variation in common laboratory miceHildebrand F, Nguyen Thi Loan A, Brinkman B, Garcia Yunta R, Cauwe B, Vandenabeele P, Liston A, Raes JGENOME BIOLOGY, 14, R4, 2013 A metagenome-wide association study of gut microbiota in type 2 diabetesQin J, Li y, Cai Z, Li S, Zhu J, Zhang F, Liang S, Zhang W, Guan Y, Shen D, Peng Y, Zhang D, Jie Z, Wu W, Qin Y, Xue W, Li J, Han L, Lu D, Wu P, Dai Y, Sun X, Li Z, Tang A, Zhong S, Li X, Chen W, Xu R, Wang M, Feng Q, Gong M, Yu J, Zhang Y, Zhang m, Hansen T, Sanchez G, Raes J, Falony G, Okuda S, Almeida M, Lechatelier E, Renault P, Pons N, Batto J, Zhang Z, Chen H, Yang R, Zheng W, Li T, Yang h, Wang K, Ehrlich S, Nielsen R, Pedersen O, Kristiansen K, Wang JNATURE, 490, 55-60, 2012 Enterotypes of the human gut microbiomeArumugam M, Raes J, Pelletier E, Le Paslier D, Yamada T, Mende D, Fernandes G, Tap J, Bruls T, Batto J, Bertalan M, Borruel N, Casellas F, Fernandez L, Gautier L, Hansen T, Hattori M, Hayashi T, Kleerebezem M, Kurokawa K, Leclerc M, Levenez F, Manichanh C, Nielsen H, Nielsen T, Pons N, Poulain J, Qin J, Sicheritz-Ponten T, Tims S, Torrents D, Ugarte E, Zoetendal E, Wang J, Guarner F, Pedersen O, De Vos W, Brunak S, Doré J, Antolin M, Artiguenave F, Blottiere H, Almeida M, Brechot C, Cara C, Chervaux C, Cultrone A, Delorme C, Denariaz G, Dervyn R, Foerstner K, Friss C, Van De Guchte M, Guedon E, Haimet F, Huber W, Van Hylckama-Vlieg J, Jamet A, Juste C, Kaci G, Knol J, Lakhdari O, Layec S, Le Roux K, Maguin E, Merieux A, Melo Minardi R, M'rini C, Muller j, Oozeer R, Parkhill J, Renault P, Rescigno M, Sanchez N, Sunagawa S, Torrejon A, Turner K, Vandemeulebrouck G, Varela E, Winogradsky Y, Zeller G, Weissenbach J, Ehrlich S, Consortium M, Bork PNATURE, 473, 174-80, 2011
26/09/2012 - Whether you have an increased risk of developing type 2 diabetes, in the future may be derived from the composition of your intestinal flora.
13/06/2012 - For the first time an international consortium of researchers, amongst whom VIB-VUB scientists, has mapped the different bacterial populations in the entire human body.
05/01/2012 - VIB and BGI are organising a genomics meeting on 15 Feb 2012 in Leuven, Belgium. Executives and investigators from both institutions will share their expertise on large scale genomcs and computational analysis
04/01/2012 - Great news to start 2012. Top journals Nature and Science are featuring research from VIB researchers at Vrije Universiteit Brussel in their 2011 highlights.
20/04/2011 - Every person’s intestinal system falls into one of three clearly distinguishable types of gut microbiota, called enterotypes, according to a metagenomics study co-authored by Jeroen Raes.
03/03/2010 - Of all the DNA that we carry around with us, less than 1% is of human composition. The rest has originated primarily from the massive amount of bacteria that live in our intestines.
Ph.D.: Ghent University, Ghent, Belgium, 2003
Post-doc.: Dept of Plant Systems Biology, VIB, Ghent, Belgium, 2003-05
Post-doc.: EMBL, Heidelberg, Germany, 2005-07
Scientist at EMBL, Heidelberg, Germany, 2007-09
VIB Group leader since September 2009