Geert De Jaeger Lab

Research focus

Biological structures and functions are generally accomplished by networks of short- and long-term molecular interactions. As a discipline, functional interactomics aims to map system-wide molecular interactions and analyze their function. Initially focused on protein-protein interactions, the field is rapidly expanding towards other interaction types, such as those between proteins and nucleic acids, or between proteins and metabolites.

A major part of our research is to develop and fine tune interactomics tools for plant research, and more specifically for the discovery of protein-protein interactions and interactions between proteins and nucleic acids. At the core of our technology lies affinity purification of macromolecular complexes. The advantage of this approach is that interactions are discovered in situ.  

The tools we develop are applied to gather knowledge on protein complexes involved in cellular growth and proliferation in order to discover new strategies for optimizing plant growth and yield. Many signalling pathways impinge on the growth and proliferation of cells in plants. However, the signaling pathways involving important growth regulators such as nutrients remain to a large extent elusive in plants. We are studying protein complexes involved in these signaling pathways, such as the TOR-SnRK1 nutrient sensors.​ 


GS(yellow), a Multifaceted Tag for Functional Protein Analysis in Monocot and Dicot PlantsBesbrugge N* Van Leene J* Eeckhout D Cannoot B Kulkarni S De Winne N Persiau G Van De Slijke E Bontinck M Aesaert S Impens F Gevaert K Van Damme D Van Lijsebettens M Inzé D Vandepoele K Nelissen H* De Jaeger G*PLANT PHYSIOLOGY, 177, 447-464, 2018* or °: authors contributed equally
An improved toolbox to unravel the plant cellular machinery by tandem affinity purification of Arabidopsis protein complexesVan Leene Jelle Eeckhout Dominique Cannoot Bernard De Winne Nancy Persiau Geert Van De Slijke Eveline Vercruysse Leen Dedecker Maarten Verkest Aurine Vandepoele Klaas Martens Lennart Witters E Gevaert Kris De Jaeger GeertNature Protocols, 10, 169-187, 2015
Dynamic Changes in ANGUSTIFOLIA3 Complex Composition Reveal a Growth Regulatory Mechanism in the Maize LeafNelissen H Eeckhout D Demuynck K Persiau G Walton A Van Bel M Vervoort M Candaele J De Block J Aesaert S Van Lijsebettens M Goormachtig S Vandepoele K Van Leene J Muszynski M Gevaert K Inzé D* De Jaeger G*PLANT CELL, 27, 1605-19, 2015* or °: authors contributed equally
The TPLATE Adaptor Complex Drives Clathrin-Mediated Endocytosis in PlantsGadeyne A* Sanchez-Rodriguez C* Vanneste S Di Rubbo S Zauber H Vanneste K Van Leene J De Winne N Eeckhout D Persiau G Van De Slijke E Cannoot B Vercruysse L Mayers J Adamowski M Kania U Ehrlich M Schweighofer A Ketelaar T Maere S Bednarek S Friml J Gevaert K Witters E Russinova E Persson S* De Jaeger G* Van Damme D*CELL, 156, 691-704, 2014* or °: authors contributed equally
Targeted interactomics reveals a complex core cell cycle machinery in Arabidopsis thalianaVan Leene Jelle Hollunder Jens Eeckhout Dominique Persiau Geert Van De Slijke Eveline Stals Hilde Van Isterdael Gert Verkest Aurine Neirynck Sandy Buffel Yelle De Bodt Stefanie Maere Steven Laukens K. Pharazyn A. Ferreira P Eloy Nubia Renne C Meyer C Faure J. D. Steinbrenner J Beynon J Larkin J. C. Van de Peer Yves Hilson Pierre Kuiper Martin De Veylder Lieven Van Onckelen H Inzé Dirk Witters E De Jaeger GeertMolecular Systems Biology, 6, 397, 2010

Job openings


Novel component in pin recycling steers auxin-mediated development

18/07/2016 - ​At the VIB Department of Plant Systems Biology, UGent, scientists identified the ROTUNDA3 protein as a regulator of the protein phosphatase 2A-driven PIN-FORMED recycling

VIB and UGent researchers identify key mechanisms of cell division in plants

11/08/2010 - Scientists from VIB and Ghent University have developed a technology that may contribute to the increase of crop yields in agriculture.

Geert De Jaeger

Geert De Jaeger

Research area(s)

Model organism(s)


​PhD: Ghent University, Ghent, Belgium, 1997
VIB Group Leader since 2002

Contact Info

VIB-UGent Center for Plant Systems BiologyUGent-VIB Research Building FSVMTechnologiepark 71 9052 GENTRoute description