Fabian Kloosterman Lab

Research focus

We are interested in the functional and structural organization of brain circuits that support the storage, expression and use of memories during behavior. In our research we use rodent models and focus on brain areas in the medial temporal lobe that are known to be critical for spatial and episodic memory. As animals learn novel associations or perform a memory-guided task, we observe the communication between large numbers of neurons using arrays of wires (‘tetrodes’) or specially designed neural probes. This allows us to study how populations represent the sensory world and to analyze the expression and use of memories during wakefulness or sleep. Combining the monitoring of neural activity with selective (opto)genetic or pharmacological perturbations we can tease apart the role of specific brain areas or cell types in memory processing. Finally, by reading out (‘decoding’) memories in real-time we may selectively alter and control the effect of these memories during behavior. The results of our work will not only shed light on the basic operation of memory systems in the brain, but also provide us with clues on where these systems fail under pathological conditions such as Alzheimer’s disease, sleep disorders and epilepsy.

Publications

Hippocampal replay of extended experienceDavidson T, Kloosterman F, Wilson mNEURON, 63, 497-507, 2009
Micro-drive array for chronic in vivo recording: drive fabricationKloosterman F, Davidson T, Gomperts S, Layton S, Hale G, Nguyen D, Wilson mJournal of visualized experiments, , , 2009
Characterizing the dynamic frequency structure of fast oscillations in the rodent hippocampusNguyen D, Kloosterman F, Barbieri R, Brown E, Wilson mFrontiers in integrative neuroscience, 3, 11, 2009
Two reentrant pathways in the hippocampal-entorhinal systemKloosterman F, Van Haeften T, Lopes Da Silva FHIPPOCAMPUS, 14, 1026-39, 2004
Electrophysiological characterization of interlaminar entorhinal connections: an essential link for re-entrance in the hippocampal-entorhinal systemKloosterman F, Van Haeften T, Witter M, Lopes Da Silva FEUROPEAN JOURNAL OF NEUROSCIENCE, 18, 3037-52, 2003

News

NERF symposium 2013

22/02/2013 - The second edition of NERF's annual neurotechnology symposium will focus on large scale approaches/technologies for studying neural circuits, neuromorphics and brain machine interfaces

NERF - where biotech and micro-electronics meet

14/12/2012 - In 2009 IMEC, KU Leuven and VIB set up a joint basic research initiative Neuro-Electronics Research Flanders (NERF) whose main mission is to unravel the function of brain circuits.

Fabian Kloosterman

Fabian Kloosterman

Research area(s)

Model organism(s)

Bio

​MSc: University of Amsterdam, Amsterdam, The Netherlands, 1994-1998
PhD: University of Amsterdam, Amsterdam, The Netherlands, 1998-2003
Post-doc: MIT / Picower Institute, Cambridge, USA, 2003-2011
NERF group leader since 2011

Contact Info

Neuro-Electronics Research FlandersImecCampus ImecKapeldreef 75 3001 LEUVENRoute description