Fabian Kloosterman Lab

Research focus

We are interested in the functional and structural organization of brain circuits that support the storage, expression and use of memories during behavior. In our research we use rodent models and focus on brain areas in the medial temporal lobe that are known to be critical for spatial and episodic memory. As animals learn novel associations or perform a memory-guided task, we observe the communication between large numbers of neurons using arrays of wires (‘tetrodes’) or specially designed neural probes. This allows us to study how populations represent the sensory world and to analyze the expression and use of memories during wakefulness or sleep. Combining the monitoring of neural activity with selective (opto)genetic or pharmacological perturbations we can tease apart the role of specific brain areas or cell types in memory processing. Finally, by reading out (‘decoding’) memories in real-time we may selectively alter and control the effect of these memories during behavior. The results of our work will not only shed light on the basic operation of memory systems in the brain, but also provide us with clues on where these systems fail under pathological conditions such as Alzheimer’s disease, sleep disorders and epilepsy.


Real-time classification of experience-related ensemble spiking patterns for closed-loop applicationsCiliberti Davide Michon Frederic Kloosterman FabianeLife, 7, e36275, 2018
Hippocampal replay of extended experienceDavidson T. J Kloosterman F. Wilson mNEURON, 63, 497-507, 2009
Characterizing the dynamic frequency structure of fast oscillations in the rodent hippocampusNguyen D. P Kloosterman F. Barbieri R Brown E Wilson mFrontiers in integrative neuroscience, 3, 11, 2009
Micro-drive array for chronic in vivo recording: drive fabricationKloosterman F. Davidson T. J Gomperts S. N Layton S. P Hale G Nguyen D. P Wilson mJove-Journal of Visualized Experiments, 2009
Two reentrant pathways in the hippocampal-entorhinal systemKloosterman F. Van Haeften T Lopes Da Silva F. HHIPPOCAMPUS, 14, 1026-39, 2004

Job openings


What makes memories stronger?

29/04/2019 - Scientists at NeuroElectronics Research Flanders (NERF) found that highly demanding & rewarding experiences result in stronger memories. These findings provide new insights into one of the most enigmatic brain features: memory consolidation

Where do rats think they are?

04/12/2018 - The rat in a maze may be one of the most classic research motifs in brain science, but a new innovation by an international collaboration of scientists shows just how far such experiments are still pushing the cutting edge of technology and neuroscience.

Neuroscientists build a tool to “read the mind” in real-time

30/10/2018 - Understanding how we learn & remember means measuring and decoding the activity patterns of complex circuits in our brain. Researchers at NERF (NeuroElectronics Research Flanders) developed a new method to measure and interpret brain activity in real-time

Fabian Kloosterman

Fabian Kloosterman

Research area(s)

Model organism(s)


​MSc: University of Amsterdam, Amsterdam, The Netherlands, 1994-1998
PhD: University of Amsterdam, Amsterdam, The Netherlands, 1998-2003
Post-doc: MIT / Picower Institute, Cambridge, USA, 2003-2011
NERF group leader since 2011

Contact Info

NERF, empowered by IMEC, KU Leuven and VIBImec CampusKapeldreef 75 3001 LEUVENRoute description