Claude Libert Lab

Research focus

Inflammation is a fundamental process, dedicated to respond to changes in the homeostasis off an organism. In principle, inflammation is beneficial, but a continuous trigger of the organism can lead to chronic inflammation, which might lead to physical or mental decline. Also an acute imbalance of homeostasis, e.g. by burn, bleeding, surgery, trauma or infection can lead to acute inflammation, which might become uncontrolled and systemic and might lead to a life-threatening form of inflammation, as we know for example during sepsis. We are mainly interested in such acute inflammation. Our mission is to understand the complex interplay of mediators and cells, as well as the impact of macrobiotics (in the gut) and metabolism is the regulation of acute inflammation. We focus on several key molecules, such as glucocorticoids, the cytokine TNF, but also on interferons and matrix metalloproteinases. We are specifically studying the involvement of the gut epithelial layer and the epithelium of the choroid plexus, an organ in the brain which forms the blood-cerebrospinal fluid barrier. Our favorite animal model is the mouse, but studies using human samples of sepsis patients and neuroinflammatory pathologies (Alzheimer and Parkinson disease) are also used in our work. We commit ourselves to come up with the identification off new players and pathways in these diseases and with new therapeutic interventions.


TNF-a inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.Dendoncker Karen* Timmermans Steven* Vandewalle Jolien Eggermont Melanie Lempiäinen Joanna Paakinaho Ville Van Hamme Evelien Dewaele Sylviane Vandevyver Sofie Ballegeer Marlies Souffriau Jolien Van Wyngene Lise Van Looveren Kelly Vanderhaeghen Tineke Beyaert Rudi De Bosscher Karolien Palvimo Jorma Van Montagu Marc@ Libert Claude@PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 116, 12942-12951, 2019* These authors contributed equally@ These authors are corresponding.
Glucocorticoid receptor dimers control intestinal STAT1 and TNF-induced inflammation in miceBallegeer M* Van Looveren K* Timmermans S Eggermont M Vandevyver S Thery F Dendoncker K Souffriau J Vandewalle J Van Wyngene L De Rycke R Takahashi N Vandenabeele P Tuckermann J Reichardt H Impens F Beyaert R De Bosscher K Vandenbroucke R Libert CJOURNAL OF CLINICAL INVESTIGATION, 128, 3265-3279, 2018* These authors contributed equally
Complete overview of protein-inactivating sequence variations in 36 sequenced mouse inbred strainsTimmermans S Van Montagu M* Libert C*PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 114, 9158-9163, 2017* These authors contributed equally
Glucocorticoid-induced microRNA-511 protects against TNF by down-regulating TNFR1Puimège L Van Hauwermeiren F Steeland S Van Ryckeghem S Vandewalle J Lodens S Dejager L Vandevyver S Staelens J Timmermans S Vandenbroucke R* Libert C*EMBO MOLECULAR MEDICINE, 7, 1004-17, 2015* These authors contributed equally
Safe TNF-based antitumor therapy following p55TNFR reduction in intestinal epitheliumVan Hauwermeiren F* Armaka M* Karagianni N* Kranidioti K Vandenbroucke R Loges S Van Roy M Staelens J Puimège L Palagani A Vanden Berghe W Victoratos P Carmeliet P Libert C* Kollias G*JOURNAL OF CLINICAL INVESTIGATION, 123, 2590-603, 2013* These authors contributed equally

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Check your favorite mouse genes in

08/08/2017 - ​VIB scientists at Ghent University uncover and display ( = mouse polymorphic sequence tags) the full richness of the mouse protein-coding genome for the mouse community.

New Horizon 2020 Project B-SMART Develops RNA-based Therapy for Neurodegenerative Diseases

01/02/2017 - Neurodegenerative diseases such as Alzheimer’s affect over 7 million people in Europe – a figure which is expected to double every 20 years as the population ages and thus poses a significant healthcare burden to European society.

Belgian scientists discover missing link in septic shock

14/09/2016 - VIB & Ghent University Researchers discovered important mechanism of sepsis, an overreaction of the body’s immune system to an infection. In this condition, the brain is unable to curb an inflammatory response, causing organ failure or ‘septic shock’.

Disruption of brain-blood barrier might influence progression of Alzheimer’s

29/09/2015 - The team of Roosmarijn Vandenbroucke in the Claude Libert Group (VIB/UGent) combined their knowledge and expertise related to inflammation with the expertise in Alzheimer’s disease present in the Bart De Strooper Group (VIB/KU Leuven).

Various avenues to counteract TNF - crucial to tackling acute inflammation

25/08/2015 - ​The cytokine TNF plays and important role in acute inflammation and in a number of auto-immune conditions. TNF needs to pass on a signal in order to execute its role. This can be achieved by binding to a receptor.

New breakthroughs in TNF biology

19/09/2013 - Two new stories from the group of Claude Libert (VIB - UGent) increase our knowledge about the mechanism of TNF release, the role of the gutin TNF’s acute toxicity and the value of TNFR1 as adrug target.

Claude Libert

Claude Libert

Research area(s)

Model organism(s)


​PhD: Ghent University, Ghent, Belgium, 1993
Postdoc: Instituto di Ricerche di Biologia Molecolare, Rome, Italy
VIB Group leader since 1997

Contact Info

VIB-UGent Center for Inflammation ResearchUGent-VIB Research Building FSVMTechnologiepark 71 9052 GENTRoute description