VIB-VUB Center for Structural Biology

Science directors: Jan Steyaert & Han Remaut

Protein complexes play critical roles in nearly all cellular functions. Accordingly, dysfunction in their assembly, lifetime, localization, or dynamics is central in many diseases, be it hereditary, sporadic or infectious.

The VIB center for Structural Biology Research studies the structure and dynamics of macromolecular complexes to explain their mode of action in health and disease. Two focus lines are protein signaling cascades and bacterial host-pathogen interactions. This structural biology work is integrated with genetic and cellular studies, thus bridging molecular and cellular resolution.

The center uses an integrated approach, combining expertise in all major techniques for structural biology (biophysics, NMR, X-ray, cryo-EM) complemented with a unique and differentiating Nanobody technology platform. It excels in translating discoveries into biotechnological and medical applications.

Jan Steyaert and Han Remaut explain their strategy

VIB-VUB Center for Structural Biology

Scientists & research:

  • Janine Brunner Lab
    Structure and function of membrane proteins - Origin and significance of membrane lipid asymmetry - Lipid transport - Intracellular ion channels - Biophysics
  • Rouslan Efremov Lab
    Electron microscopy - membrane proteins - molecular machines - single particle analysis - image processing
  • Remy Loris Lab
    protein structure and conformation - intrinsic disorder and dynamics - bacterial persistence - plant cell cycle
  • Joris Messens Lab
    redox - ROS - oxidative stress - protein electron transfer - thiol/disulfide exchange
  • Han Remaut Lab
    host-pathogen interaction - protein secretion - bacterial cell surfaces - anti-virulence therapeutics
  • Jan Steyaert Lab
    Nanobody technology - G protein mediated signalling - Protein protein interactions
  • Peter Tompa Lab
    Structural Biology - IDPs - Disordered Proteins - In-cell NMR - Bioinformatics
  • Charles Van der Henst Lab
    Microbiology and Infectiology, Antimicrobial resistances, Bacterial virulence, Drug discovery, Host-pathogen interactions
  • Shoshana Wodak Lab
    protein interactions - protein stability - integrative computational proteomics - atomic scale


VIB-VUB Center for Structural Biology
Building E Pleinlaan 2  1050 BRUSSEL BELGIUM
+32 2 629 19 23
+32 2 629 19 81


Click here for an overview of the supporting staff

Hosting: VIB Nanobody Core

Nanobodies® are an extremely useful class of molecules for research, diagnostics and therapeutics in human and animal health. You can use them in a wide variety of fields, such as immunohistochemistry, immunomodulation, intracellular expression (intrabodies) and biosensor-applications. As proteomics tools, you can deploy them for expression profiling, physical mapping of proteins, protein-protein interaction studies, functional analysis and (in)activation of genens. Developed at the Vrije Universiteit Brussel, Belgium, the powerful Nanobody® technology is now available to both academic as to non-academic researchers through the VIB Nanobody Core.
For more information:

VIB Nanobody Core