VIB-UAntwerp Center for Molecular Neurology

Science director: Christine Van Broeckhoven

The overall objective of the VIB Center for Molecular Neurology (CMN) is to enhance our current understanding of the biology of the nervous system during healthy aging and in relation to aging-related diseases. The new information will be translated to the clinic as well as to experimental work to gain a comprehensive view of the disease process ultimately contributing to the development of effective preventive interventions and etiological treatments. To achieve this objective, CMN defines two main goals: i) to improve our knowledge on the complex molecular etiology of age-related neurological diseases and ii) to create effective translational pipelines and potential therapies that are specifically tailored to well-characterized patient groups. In this way, the CMN’s mission will thrive on and complement the strategic initiative of VIB on translational research, adding to the visibility and raising further the international standing of our institute. 

Our efforts have a strong translational directionality, where the patient has a central position in the research process both at the conceptual and the experimental level. An invaluable strength comes from the combination of extended patient biobanking, molecular signature discovery and high-dimensionality data integration, within a coherent system for therapeutic and diagnostic strategy creation. We strongly believe that a higher-order interrogation of data from a whole-organism-wide appreciation of neurodegenerative diseases is required for the generation of the most effective therapeutics that exert their actions in an integrative systems-level manner.

Our key goals:

         1.   to identify causal genes and disease modifying genes that contribute to genetic risk and clinical                               expression 
         2. to analyze the clinical trajectory, including the early asymptomatic phase of disease, in large families                    with inherited disease 
         3. to unravel the molecular mechanisms underlying the onset and progression of disease 
         4. to generate a holistic understanding of age-related neurological diseases by discovering genetic,                            epigenetic, transcriptomic, and proteomic signatures of disease amenable to therapeutic targeting
         5. to develop translationally-effective cell and animal models of disease for mechanistic investigation,                     diagnostic interpretation and therapeutic intervention 
         6.   to identify (noninvasive) biomarkers and therapeutic strategies for personalized medicine

 

VIB-UAntwerp Center for Molecular Neurology

Scientists & research:

  • Peter De Jonghe Lab
    peripheral neuropathies - epilepsy - progressive external ophthalmoplegia - spastic paraplegias - gene mapping and cloning
  • Albena Jordanova Lab
    molecular genetics – neurodegeneration – aminoacyl-tRNA synthetases – Gypsy/Roma population
  • Stuart Maudsley Lab
    multifactorial neurodegenerative diseases - genomics - GPCR signaling - proteomic - transcriptomic
  • Christine Van Broeckhoven Lab
    Alzheimer’s disease - frontotemporal dementia - Parkinson's disease - genetics - genomics – translational neurosciences

Contact

VIB-UAntwerp Center for Molecular Neurology
Gebouw V Campus Drie EikenUniversiteitsplein 1  2610 ANTWERPEN BELGIUM
Tel:
+32 3 265 11 02
Fax:
+32 3 265 11 13

Click here for an overview of the supporting staff

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