Science directors: Jan Steyaert & Han Remaut
Protein complexes play critical roles in nearly all cellular functions. Accordingly, dysfunction in their assembly, lifetime, localization, or dynamics is central in many diseases, be it hereditary, sporadic or infectious.
The VIB center for Structural Biology Research studies the structure and dynamics of macromolecular complexes to explain their mode of action in health and disease. Two focus lines are protein signaling cascades and bacterial host-pathogen interactions. This structural biology work is integrated with genetic and cellular studies, thus bridging molecular and cellular resolution.
The center uses an integrated approach, combining expertise in all major techniques for structural biology (biophysics, NMR, X-ray, cryo-EM) complemented with a unique and differentiating Nanobody technology platform. It excels in translating discoveries into biotechnological and medical applications.
Jan Steyaert and Han Remaut explains their strategy
VIB-VUB Center for Structural Biology
Scientists & research:
- Rouslan Efremov Lab
Electron microscopy - membrane proteins - molecular machines - single particle analysis - image processing
- Remy Loris Lab
protein structure and conformation - bacterial TA modules - lectins - structural glycobiology
- Joris Messens Lab
redox - ROS - oxidative stress - protein electron transfer - thiol/disulfide exchange
- Han Remaut Lab
host-pathogen interaction - protein secretion - bacterial cell surfaces - anti-virulence therapeutics
- Jan Steyaert Lab
Nanobody technology - G protein mediated signalling - Protein protein interactions
- Peter Tompa Lab
Structural Biology - IDPs - Disordered Proteins - In-cell NMR - Bioinformatics
- Shoshana Wodak Lab
protein interactions - protein stability - integrative computational proteomics - atomic scale
Click here for an overview of the supporting staff