Postdoctoral Position in the Advanced Live Cell Imaging group of Daniel Van Damme

Description

Within the framework of an ERC Consolidator project, An initial 2-year postdoctoral position is available in the Advanced Live Cell Imaging group of Daniel Van Damme at The VIB/UGent Department of Plant Systems Biology to investigate the ultrastructure of the plant endocytic TPLATE complex (TPC).

The TPC has its evolutionary origin in between the emergence of COPI and the functional specification of the AP complexes. While the TPC remained essential for plants, it was evolutionary lost in yeasts and animal cells, indicating that endocytosis operates differently in plants (Gadeyne et al., Cell 2014: Hirst et al., Elife 2014).

The project aims to generate structural insight into membrane recruitment and cargo identification of the TPC as well as its interplay with the evolutionary conserved AP-2 complex. It will combine structural biology approaches including complex purification from plants, yeast, E. coli and insect cells with single particle EM imaging (negative stain and cryo-EM). The project will run in close collaboration with structural biology groups within the VIB institute (Savvas Savvides, VIB/UGent and Rouslan Efremov, VIB/VUB) and will therefore have access to a plethora of structural biology techniques. It will also be able to benefit from the possibilities of the European Instruct structural biology platform (https://www.structuralbiology.eu/).

Profile

  • ​Motivated candidates with a PhD and a proven track record in structural biology and/or molecular biology (e.g. protein/complex purification, recombinant protein biochemistry, structural EM imaging).
  • Prior experience in the field of endocytosis is an asset.

We offer

The successful candidate will have the first hand in the structural elucidation of an enigmatic endocytic complex and will become part of a lively research group with a long track record on unravelling the role of this key endocytic complex in plants (Van Damme et al., Plant Journal 2004; Van Damme et al., Plant Cell 2006; Van Damme et al PNAS 2011; Gadeyne et al., Cell 2014).

 

How to apply?

  • ​Interested candidates are asked to apply online. Please upload your CV, a statement of interest focusing on the project and the contact details of two referees.
  • Selected candidates will be invited for an interview or skype meeting.
  • The project can start immediately and the call will remain open until a suitable candidate is found.

Creation date:

6 December 2016

Function:

Postdocs

Center:

VIB Center for Plant Systems Biology,

Location:

Gent

Why work at VIB?

Top reasons to join VIB