This biomarker can be used to scientifically prove the effect of cosmetics, food supplements, medicines, dietary compositions and other ingredients on both humans and animals.
It can also be used to track the physiological age of cells, animals or humans based on analysis of cell lysate, serum, skin fluid or other biological fluid.
Summary of the invention
VIB developed proprietary technology to measure and quantify the glyco-profile of N-linked glycoproteins, which can be used on any biological fluid (serum, cell lysate, skin fluid, …). Based on the ratios of different peaks of N-glycoproteins in serum, an “aging marker” or “health status marker” was found that can be used as a biomarker for the physiological age status.
A significant positive correlation was found between this biomarker and the age of human subjects. Importantly, the aging marker correlates with the biological age or the physiological state rather than purely with the number of years. The evidence for this was two-fold:
· Serum samples of a subject with Werner syndrome, a rare disease with a premature aging phenotype, was consistent
· This biomarker has a consistent profile in calorie restricted diet conditions, which is well known to extend the life span of rodents. The aging marker of mice and rats on a calorie restricted diet shows a younger biological profile than the counterpart animals with an ��ad libitum” access to food.