Profiles of sugars derived from N-linked glycoproteins from blood serum can be used as biomarkers to diagnose or to monitor the progress of Alzheimer’s disease.
Summary of the Invention
A VIB-developed, high-throughput, high-sensitivity and robust assay to measure and quantify the various N-glycans of biological fluids has unraveled differences in serum glycoproteins between Alzheimer’s disease patients, non-AD dementia patients and non-demented age-matched controls. This non-invasive biomarker promises an accurate diagnosis with a AUC of 90% in an ROC curve.
- Non invasive serum marker
- Diagnosis possible in early stage of disease, when therapy is likely most efficacious
- Biomarker to monitor progress of the Alzheimer’s disease
- Clinical aid to diagnose Alzheimer’s disease from non-Alzheimer’s dementia
- Predictive selection of clinical trial cohorts of subjects